Optimization models have often been useful in attempting to understand the adaptive significance of behavioral traits. Originally such models were applied to isolated aspects of behavior, such as foraging, mating, or parental behavior. In reality, organisms live in complex, ever-changing environments, and are simultaneously concerned with many behavioral choices and their consequences. This target article describes a dynamic modeling technique that can be used to analyze behavior in a unified way. The technique has been widely used in behavioral studies of (...) insects, fish, birds, mammals, and other organisms. The models use biologically meaningful parameters and variables, and lead to testable predictions. Limitations arise because nature's complexity always exceeds our modeling capacity. (shrink)

This volume, which is part of the Clarendon Aristotle Series, offers a clear and faithful new translation of Books II to IV of Aristotle's Nicomachean Ethics, accompanied by an analytical commentary focusing on philosophical issues. In Books II to IV, Aristotle gives his account of virtue of character in general and of the principal virtues individually, topics of central interest both to his ethical theory and to modern ethical theorists. Consequently major themes of the commentary are connections on the one (...) hand with other relevant Aristotelian texts and on the other with modern writings, both text-related and thematic. Since the main aim of the volume is to make Aristotle's thought as accessible as possible to readers who do not know Greek, considerable care is taken to elucidate both his technical vocabulary and significant features of his Greek idiom. C. C. W. Taylor also provides systematic comparisons with other translations into English and other languages, and frequent references to other commentaries, ancient, medieval, and modern. These features make the work useful to other scholars in the field as well as to students of philosophy, both undergraduate and graduate.In view of the widespread contemporary interest in the topic of virtue, the volume should appeal to students of ethics and to any reader who is concerned to see how fundamental questions of life and conduct were approached in a culture significantly different from our own. (shrink)

Fitting the Mind to the World explores the brain's remarkable capacity to adapt to its current visual environment. Leading vision researchers explore how visual experience alters the adult brain, fitting the mind to the world, and ensuring the efficient coding of sensory signals. They demonstrate how this plasticity affects every aspect of our visual experience, from the perception of movement and colour, to the perception of subtle, social and emotional information in human faces.

The aim of this paper is to explore the conditions under which generalisation from single case studies, in the sense of making inferences concerning a wider class of phenomena beyond a case, is reasonable. Two sets of conditions, in particular, provide the basis for our consideration of this issue. The first is an exploration of the impressive amount of empirical knowledge that is contained within the theories that are used to make observations, to classify phenomena, and to understand and interpret (...) cases. The second is recognition of the role of a pattern of inference known as abduction, or inference to the best explanation, in drawing conclusions from case studies. It is argued that these two conditions, when applied to the procedures for conducting case studies, can be used to defend, as reasonable, the making of certain provisional generalisations from single cases. An epistemological procedure for testing and further justifying these generalisations, with a particular emphasis on dealing with the problem of confirmation bias, is then discussed and recommended. (shrink)

The aim of this paper is to explore the conditions under which generalisation from single case studies, in the sense of making inferences concerning a wider class of phenomena beyond a case, is reasonable. Two sets of conditions, in particular, provide the basis for our consideration of this issue. The first is an exploration of the impressive amount of empirical knowledge that is contained within the theories that are used to make observations, to classify phenomena, and to understand and interpret (...) cases. The second is recognition of the role of a pattern of inference known as abduction, or inference to the best explanation, in drawing conclusions from case studies. It is argued that these two conditions, when applied to the procedures for conducting case studies, can be used to defend, as reasonable, the making of certain provisional generalisations from single cases. An epistemological procedure for testing and further justifying these generalisations, with a particular emphasis on dealing with the problem of confirmation bias, is then discussed and recommended. (shrink)

Unraveling the molecular detail of insulin receptor activation has proved challenging, but a major advance is the recent determination of crystallographic structures of insulin in complex with its primary binding site on the receptor. The current model for insulin receptor activation is that two distinct surfaces of insulin monomer engage sequentially with two distinct binding sites on the extracellular surface of the insulin receptor, which is itself a disulfide‐linked (αβ)2 homodimer. In the process, conformational changes occur both within the hormone (...) and the receptor, the latter resulting in the disruption of the intracellular interactions that hold the kinase domains in their basal state and in the initiation of the phosphorylation events that drive insulin signaling. The purpose of this paper is to summarize the extant structural data relating to hormone binding and how it effects receptor activation, as well as to discuss the issues that remain unresolved. (shrink)

This volume, which is part of the Clarendon Aristotle Series, offers a clear and faithful new translation of Books II to IV of Aristotle's Nicomachean Ethics, accompanied by an analytical commentary focusing on philosophical issues. In Books II to IV, Aristotle gives his account of virtue of character in general and of the principal virtues individually, topics of central interest both to his ethical theory and to modern ethical theorists. Consequently major themes of the commentary are connections on the one (...) hand with other relevant Aristotelian texts and on the other with modern writings, both text-related and thematic. Since the main aim of the volume is to make Aristotle's thought as accessible as possible to readers who do not know Greek, considerable care is taken to elucidate both his technical vocabulary and significant features of his Greek idiom. C. C. W. Taylor also provides systematic comparisons with other translations into English and other languages, and frequent references to other commentaries, ancient, medieval, and modern. These features make the work useful to other scholars in the field as well as to students of philosophy, both undergraduate and graduate.In view of the widespread contemporary interest in the topic of virtue, the volume should appeal to students of ethics and to any reader who is concerned to see how fundamental questions of life and conduct were approached in a culture significantly different from our own. (shrink)

Current models of insulin binding to the insulin receptor (IR) propose (i) that there are two binding sites on the surface of insulin which engage with two binding sites on the receptor and (ii) that ligand binding involves structural changes in both the ligand and the receptor. Many of the features of insulin binding to its receptor, namely B‐chain helix interactions with the leucine‐rich repeat domain and A‐chain residue interactions with peptide loops from another part of the receptor, are also (...) seen in models of relaxin and insulin‐like peptide 3 binding to their receptors. We show that these principles can likely be extended to the group of mimetic peptides described by Schäffer and coworkers, which are reported to have no sequence identity with insulin. This review summarizes our current understanding of ligand‐induced activation of the IR and highlights the key issues that remain to be addressed. (shrink)

This paper considers the prospects for objectivity in reasoning strategies in response to empirical studies that apparently show systematic culture‐based differences in patterns of reasoning. I argue that there is at least one modest class of exceptions to the claim that there are alternative, equally warranted standards of good reasoning: the class that entails the solution of certain well‐structured problems which, suitably chosen, are common, or touchstone, to the sorts of culturally different viewpoints discussed. There is evidence that some cognitive (...) tasks are seen in much the same way across cultures, not least by virtue of the common run of experiences with the world of material objects in early childhood by creatures with similar cognitive endowments. These tasks thus present as similarly structured sets of claims that have similar priority: what is framed, and what is bracketed, or held constant in the background, is shown to be naturally common across cultures. As a consequence, a normative view of reasoning and, by implication, critical thinking can be defended. While this might be a modest sense of objectivity, the high level of intercultural articulation that is able to occur among people of different backgrounds suggests that it provides cognitive scaffolding for a lot of other reasoning tasks as well. (shrink)

This paper considers the prospects for objectivity in reasoning strategies in response to empirical studies that apparently show systematic culture‐based differences in patterns of reasoning. I argue that there is at least one modest class of exceptions to the claim that there are alternative, equally warranted standards of good reasoning: the class that entails the solution of certain well‐structured problems which, suitably chosen, are common, or touchstone, to the sorts of culturally different viewpoints discussed. There is evidence that some cognitive (...) tasks are seen in much the same way across cultures, not least by virtue of the common run of experiences with the world of material objects in early childhood by creatures with similar cognitive endowments. These tasks thus present as similarly structured sets of claims that have similar priority: what is framed, and what is bracketed, or held constant in the background, is shown to be naturally common across cultures. As a consequence, a normative view of reasoning and, by implication, critical thinking can be defended. While this might be a modest sense of objectivity, the high level of intercultural articulation that is able to occur among people of different backgrounds suggests that it provides cognitive scaffolding for a lot of other reasoning tasks as well. (shrink)

The basic form of experiencing process as such, then, lies in the apprehension of an object changing through an ordered sequence of states towards an end state. The sequence is grasped in the light of the final state of things which stands in close relation to the central noema of "changing object" in terms of which the phases of the sequence are recognized and related. The central noema is itself an emergent property of the identification of the sequence of states (...) as "pertaining to the same something." This complex, not to say convoluted, constitution is iteratively established through polythetic acts in which change itself is grasped and sequence evidenced through the positing of possible sequences in the light of the intuition of succession. Eventually the whole sequence may be grasped monothetically and the process experienced as such as a whole. This prototype of process itself provides a basic form by which the events of intentional life may be ordered. The core experience, that objects do change in an ordered manner towards a defined and defining end may provide a way of meaningfully structuring experience. Thus for example, the succession Sii to Siii may be experienced as such. That succession may lead to a question like "towards what end does this succession tend?" More germane to the present argument, a particular state of things may lead to the question "by what process has this state of things come about?" In both these cases, the prototype of process leads to the attempt to interpret the succession or the state of things in terms of orderly change through time and in this way the intuition of process, in its own right, may provide a structure in which the phenomena of consciousness may be experienced and meaningfully related. (shrink)

This chapter contains sections titled: Introduction Reviewing the Arguments Problems, Solutions and Objectivity Conclusion References.

The purpose of this paper is to outline some new developments in a mature research program that sees administrative theory as cohering with natural science and uses a coherence theory of epistemic justification to shape the content and structure of administrative theory. Three main developments are discussed. First, the paper shows how to deal with the evaluation of theories where there is a demand that a theory needs to be context relevant, but also comprehensive. The solution is to allow context (...) to determine the scope of comprehensiveness. Second, the paper develops an argument structure employing a coherentist epistemology for how ethical claims can be incorporated into administrative theories. Finally, the paper, drawing on research in neuroscience, argues for the relevance of emotion in rational decision-making. Contrary to the belief that emotion compromises rationality, the paper argues that it is essential for rationality. (shrink)

Recent debate has arisen in the neuroethics literature on the extent to which deep brain stimulation (DBS) may cause changes to core personal traits. This has prompted calls for more empirical data...

A two stage model was developed and tested to explain how ethical leadership relates to followers’ ethical judgment in an organizational context. Drawing on social learning theory, ethical leadership was hypothesized to promote followers’ self-leadership focused on ethics. It was found that followers’ perceived accountability fully accounts for this relationship. In stage two, the relationship between self-leadership focused on ethics and moral judgment in a dual decision-making system was described and tested. Self-leadership focused on ethics was only related to moral (...) judgment when followers use active judgment as opposed to their intuition. This provides support that a deliberate application of self-leadership focused on ethics leads to higher moral judgment. Theoretical and practical implications as well as future research opportunities are discussed. (shrink)

Michael A PetersBeijing Normal UniversityChatGPT is an AI chatbot released by OpenAI on November 30, 2022 and a ‘stable release’ on February 13, 2023. It belongs to OpenAI’s GPT-3 family (generativ...

The phenomenon of multi-used stock photography in the news contradicts the photojournalism professional values of truthful and emotional depictions. This reality echoes other false images increasingly appearing in the media, including deepfakes and artificial intelligence. In the present study, a two (stock and staff photo) by two (positive and negative valence) quasi-experiment is conducted. The dependent variables include: 1) credibility; 2) self-reported arousal level; 3) emotional valence perceptions; 4) fixation duration; and 5) fixation count. Participants viewed staff photos as more (...) credible in both positive and negative valences. Negative photos were perceived as slightly less credible. Stock and staff photos were similarly arousing, received similar valence perceptions, and had similar gaze fixations and durations. Overall, participants perceived the genuine emotion portrayed truthfully in photojournalism as opposed to the faux emotion acted out in stock photos. (shrink)

This article proposes an action guide to making decisions regarding the ethical allocation of resources that affect access to healthcare services offered by community-based healthcare organizations. Using the filter of empirical data from a study of decision making in two community-based healthcare organizations, we identify potentially relevant conceptual guidance from a review of frameworks and action guides in the public health, health policy, and organizational ethics literature. We describe the development of this action guide. We used data from a prior (...) empirical study of the values that influence decision making about the allocation of resources in particular types of community-based healthcare organizations. We evaluated, organized, and specified the conceptual guidance we found in 14 frameworks for ethical decision making. The result is an action guide that includes four domains that are relevant to the context of the decision to be made, eight domains that are relevant to the process of the decision to be made, and 15 domains that are relevant to the criteria of the decision to be made. We demonstrate the potential use of this action guide by walking through an illustrative resource allocation decision. The action guide provides community-based healthcare organizations with a conceptually grounded, empirically informed framework for ethical decision making. (shrink)

Bringing between two covers the most influential and accessible articles on Plato's Republic, this collection illuminates what is widely held to be the most important work of Western philosophy and political theory. It will be valuable not only to philosophers, but to political theorists, historians, classicists, literary scholars, and interested general readers.